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Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway

Beiging of white adipose tissue has potential antiobesity and antidiabetes effects, yet the underlying signaling mechanisms remain to be fully elucidated. Here we show that adipose-specific knockout of Rheb, an upstream activator of mechanistic target of rapamycin complex 1 (mTORC1), protects mice from high-fat diet–induced obesity and insulin resistance. On the one hand, Rheb deficiency [...]

April 22, 2017 | 0 Comments More

Management of Inpatient Hyperglycemia and Diabetes in Older Adults

Guillermo E. UmpierrezApr 1, 2017; 40:509-517 : Most-Read Full-Text Articles

April 21, 2017 | 0 Comments More

Diabetes study raises treatment hope for kidney disease patients

Scientists have identified a key molecule linked to kidney disease in people with diabetes. Diabetes News From Medical News Today

April 21, 2017 | 0 Comments More

Deletion of ATF4 in AgRP Neurons Promotes Fat Loss Mainly via Increasing Energy Expenditure

Although many functions of activating transcription factor 4 (ATF4) are identified, a role of ATF4 in the hypothalamus in regulating energy homeostasis is unknown. Here, we generated adult-onset agouti-related peptide neuron–specific ATF4 knockout (AgRP-ATF4 KO) mice and found that these mice were lean, with improved insulin and leptin sensitivity and decreased hepatic lipid accumulation. Furthermore, [...]

April 20, 2017 | 0 Comments More