Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis

Fibrosis of adipose tissue induces ectopic fat accumulation and insulin resistance by inhibiting adipose tissue expandability. Mechanisms responsible for the induction of adipose tissue fibrosis may provide therapeutic targets but are poorly understood. In this study, high-fat diet (HFD)–fed wild-type (WT) and iNOS–/– mice were used to examine the relationship between nitric oxide (NO) produced [...]

August 27, 2016 | 0 Comments More

Diabetes-related vision loss growing worldwide

The number of people worldwide with vision loss from diabetic retinopathy is rising, representing an increasing proportion of the blind and sight-impaired. Diabetes News From Medical News Today

August 27, 2016 | 0 Comments More

Celiac Disease Negatively Influences Lipid Profiles in Young Children With Type 1 Diabetes: Effect of the Gluten-Free Diet

Silvana Salardi, Giulio Maltoni, Stefano Zucchini, Dario Iafusco, Santino Confetto, Angela Zanfardino, Sonia Toni, Barbara Piccini, Maximiliano Zioutas, Marco Marigliano, Vittoria Cauvin, Roberto Franceschi, Ivana Rabbone, Barbara Predieri, Riccardo Schiaffini, Alessandro Salvatoni, Petra Reinstadler, Giulia Berioli, Valentino Cherubini, Giuseppe dAnnunzio, for the Diabetes Study Group of the Italian Society of Pediatric Endocrinology and Diabetology (ISPED)Aug [...]

August 26, 2016 | 0 Comments More

Positron Emission Tomography to Assess the Outcome of Intraportal Islet Transplantation

No imaging methodology currently exists to monitor viable islet mass after clinical intraportal islet transplantation. We investigated the potential of the endocrine positron emission tomography (PET) marker [11C]5-hydroxytryptophan ([11C]5-HTP) for this purpose. In a preclinical proof-of-concept study, the ex vivo and in vivo [11C]5-HTP signal was compared with the number of islets transplanted in rats. [...]

August 25, 2016 | 0 Comments More