Functional Human Beige Adipocytes From Induced Pluripotent Stem Cells

Activation of thermogenic beige adipocytes has recently emerged as a promising therapeutic target in obesity and diabetes. Relevant human models for beige adipocyte differentiation are essential to implement such therapeutic strategies. We report a straightforward and efficient protocol to generate functional human beige adipocytes from human induced pluripotent stem cells (hiPSCs). Without overexpression of exogenous [...]

May 23, 2017 | 0 Comments More

The Effect of Insulin on the Disposal of Intravenous Glucose: Results from Indirect Calorimetry and Hepatic and Femoral Venous Catheterization

R A DeFronzoDec 1, 1981; 30:1000-1007Original Contribution : Most-Cited Full-Text Articles

May 21, 2017 | 0 Comments More

Hepatic Activation of the FAM3C-HSF1-CaM Pathway Attenuates Hyperglycemia of Obese Diabetic Mice

FAM3C is a member of the family with sequence similarity 3 (FAM3) gene family, and this study determined its role and mechanism in regulation of hepatic glucose/lipid metabolism. In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression [...]

May 20, 2017 | 0 Comments More

Role of oxidative stress in diabetic complications: a new perspective on an old paradigm

JW BaynesJan 1, 1999; 48:1-9Articles : Most-Cited Full-Text Articles

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